The film begins on New Year’s Eve 2001 when Angelica attempts suicide by somewhat theatrically cutting her wrists in the bath. Over the weeks that follow we learn all about the complexities of her life and her three best friends, the quartet of the title.

1980 film by Carlo Lizzani

Salvatore Di Donato is one of the most feared and respected members of the Mafia in Naples. His wife, Assuntina, is a young theater actress. During a pilgrimage to Madonna of the Arch, Salvatore and Assuntina meet Margaret, a woman proud and beautiful. Salvatore falls in love with her, leaves Assuntina and goes to live with his new love. Margaret, however, is a strong woman, free, resistant to bring controlled by Salvatore, and ultimately he is forced to return home, ridiculed in the eyes of all.

A couple of young movie makers have secretly filmed for over a year what was going on in a hotel room, trying to realize a "live act" of common people living their life. They get in touch with old and money-tight producer Mengaroni to edit their movie, but while they contact the accidental actors for gathering authorization, he starts to manipulate their work.

1982 film by Pasquale Festa Campanile

The people of Jerusalem are suffering under the reign of Herod, and are hoping to be delivered from the Roman occupiers by the Messiah whose arrival, it is rumored, is to take place very soon. Unlike his nephew Judas, who wants to join the zealots (freedom fighters), 35 year old widower Joseph is not interested in participating in any fighting against the Romans.

Based on the story of the woman recently brought to trial on charges of moral plagiarism and witchcraft.

Two back-to-back stories that deals with two "taboo" themes, the celibacy of the clergy in the episode of Renato Pozzetto and the homosexuality in the one with Nino Manfredi.

Dea, gynecologist and scientist, and her colleagues have for the last few months been preparing a campaign against the local pharmaceutical industry. A campaign, which is linked to Dea's published findings concerning harmful side effects of the pill. For years Dea and her husband Rheinhard have been defending opposing sides as to the culpability of the company. Rheinhard, who is also a leading scientist like Dea, is a high-ranking employee of the concern. In the meantime Reinhard and Dea's 2 daughters have grown up. The daughter of the company's boss, Johanna, is Dea's assistant and Reinhard's lover.