An underground revolutionary group struggles against internal strife to stage urban guerilla attacks against a fictionalized fascist regime in the United States. Interspersed throughout the narrative are rhetorical sequences that explain the philosophy of radical action and restrain the melodrama inherent in the thriller genre.

Route One is the first major U.S. highway. 5000 km along the Atlantic coast, from the Canadian border to the tip of Florida. Doc, a physician who spent many years in Africa, returns to the U.S. and decides to reconnect with his home country by walking the legendary Route One.