Kate Burns is looking for the perfect match online when she swipes and meets Walker Stevenson, a wealthy jet-setting art dealer. After Kate falls for the dashing dealer, she learns Walker is a hustler who cons women out of their money.

After takeoff, flight attendant Nora gets a call from a stranger blackmailing her into poisoning a passenger in exchange for her family. One way or another, someone is going to die during this flight as they get closer to their destination.