Moving Picture World described the film: "There is a small need to describe this subject as the poem of Lord Tennyson is so well known, so suffice it to say that this Biograph subject is an unusually faithful portrayal of that beautiful romance of Enoch Arden, Annie Lee and Philip Ray, taken in scenes of rare beauty". This is the combined feature version of Enoch Arden Parts I and II.

Two sisters want to know whether there is romance in their future. One sister pulls the petals off of a flower, while the other has her fortune told by a gypsy. When the gypsy tells the fortune so as to serve his own purposes, complications soon develop.

Hard-working Dave loves Grace, but she rejects him for a flashier suitor. Grace is blinded in an accident, and her suitor abandons her. Meanwhile, Dave also goes blind from eye strain caused by overwork. Dave learns of Grace's misfortune and gives a doctor the money he was saving for his own operation, so her sight can be restored.

Annie remains faithful to her husband, Enoch, even though he's been lost at sea for many years. Finally her grown children convince her to marry Philip, her former suitor. Enoch is rescued from the deserted isle where he has been stranded, and returns home. He discovers Annie's new life, and decides not to interrupt her happiness.

Little Billy, the bootblack, finding luck against him, decides to move to some other town. To do this he must walk, as he hasn’t the wherewithal for a railroad ticket. While trudging through the country, he falls into the hands of a couple of sinister-looking tramps, and they at once, by threats, force him to beg for them. A day or so later, the tramps hold up an old man, and while procuring his money throw him down with such force as to unintentionally kill him. Panic-stricken at their awful deed, they feel that the boy’s knowledge of the affair will prove disastrous for them, and so they decide to get rid of him. Through the sagacity of a dog the boy is saved and the tramps are captured.

A wagon train heading west across the great desert runs out of water, and is attacked by Indians. One man -- their last hope -- is sent out to find water.

During the Civil War a young soldier loses his nerve in battle and runs away to his home to hide; his sister puts on his uniform, takes her brother's place in the battle, and is killed. Their mother, not wanting the shameful truth to become known, closes all the shutters (hence the film's title) and keeps her son's presence a secret for many years, though two boyhood chums stumble upon the truth...

A Confederate officer is called off to war. He leaves his wife and daughter in the care of George, his faithful Negro servant. After the officer is killed in battle, George continues in his caring duties, faithful to his trust.

Two Johns, a Confederate and an Union soldier, leave their families to go to the front. After a skirmish they end up separated from their respective sides, the Union soldier shoots the Confederate, but he has to escape and look for refuge in the house of his enemy.

Enoch Arden, a humble fisherman, marries Annie Lee. He signs on as a sailor to make more money to support their growing family. A storm wrecks his ship, but Enoch swims to a deserted island. Annie waits vainly for his return.