Prof. Andrew Gentling, in Los Angeles to help found a new college, is inveigled by old flame Catherine Sykes into a midnight drive. Next day Catherine is missing, believed killed; friend Martha convinces Andrew that he's a prime suspect and should investigate before he's arrested. But this only puts Andrew in a more deadly kind of danger.

In Renaissance Florence, a Florentine trader meets a shipwrecked stranger, who introduces himself as Tito Melema, a young Italianate-Greek scholar. Tito becomes acquainted with several other Florentines, including Nello the barber and a young girl named Tessa. He is also introduced to a blind scholar named Bardo de' Bardi, and his daughter Romola. As Tito becomes settled in Florence, assisting Bardo with classical studies, he falls in love with Romola.

A straitlaced turn-of-the-century father presides over a family of boys and the mother who really rules the roost.

A society gigolo goes after a rich mother and her daughter, but tries to find true happiness with his girlfriend, who is neither rich nor in "society."