Mimi, an orphan, is taken in by a drunken innkeeper and becomes a domestic. She meets Rudolphe, scion of a well-to-do family, who rescues her from the unwanted advances of a drunken hotel guest. They fall madly in love, but Rudolphe's uncle, M. Durandin, wants Rudolphe to marry a family friend, Madame de Rouvre, and writes Mimi a letter, telling her that she is ruining Rudolphe's life. Musette and Marcel, friends of Mimi, also try to break up the romance by introducing Mimi to other men, and Rudolphe becomes jealous and leaves her. Brokenhearted, Mimi declines in health and eventually throws herself into the river but is rescued and taken to the hospital. Realizing it is only a matter of time before she dies, she drags herself back to the room where she and Rudolphe were happiest. Rudolphe is there and she dies knowing that he loves her.

In Czarist Russia, attractive Anna Ivanovna has consecrated her life to work among Russia's persecuted poor. She dispenses food, medicine, and funds to the needy, from a busy charity headquarters. Two men, separate in station, are in love with Ivanovna: Poor doctor Paul helps as much as he can, and wealthy merchant Serge donates money. The relentless and lascivious Chief of Police, also attracted by Ivanova's beauty and virtue, determines to possess her, and sentences all three to fifteen years in Siberia and East Russia on false charges.