After an incredible night out with her girlfriends, Vickie Palmer is wrenched from her peaceful slumber and cast mercilessly into a world spinning out of control. Writhing half naked on the cold porcelain tile of her bathroom floor, Vickie desperately tries to piece together the tragic turn of events that has twisted her once carefree life into a nightmare of pain and suffering. But when she discovers the truth, will it be too late to save her from eternal damnation?

When loser Duke, who has screwed up every hair-brained scheme he's ever come up with, accidentally falls off a cruise ship and wakes up on a mysteriously abandoned, top secret government island, he discovers that it's overrun with mutants and monsters from a failed 1980s DARPA "super soldier" project to stop the 2nd Cold War.