The leader of a South African Nation is imprisoned. His followers, led by Zabo, hijack a plane with the intent to use the passengers as hostages to trade for his release. They select a plane carrying a religious leader to use as their main hostage. They soon learn that they have an added bonus of the daughter and grandson of Colonel Shaw, a bigwig in the country. The grandson all the while has to cope with the dual problems of being hijacked and held hostage while needing a kidney transplant. The hijackers have everything in their favor, except that the colonel's daughter is the sweetheart of Major Sam Striker. Striker puts together a band of mercenaries and sets about freeing the hostages.

After Leila, his boss's daughter, is kidnapped by psychopathic plague victim Decker, chauffeur Chazz teams up with plague-infected mercenary Luger to penetrate the toxic & off-limits Plague Zone and bring her back alive.

After a series of gory murders commited by mobs of townspeople against visiting tourists, the corpses appear to be coming back to life and living normally as locals in the small town.