Young troublemaker Michael learns about his native American roots from his grandfather who lives at a reservation. The boy starts to bond with a horse his grandfather buys him, whom he decides to call 'Three Warriors'. When a trio of horse rustlers get hold of the horse, Michael gets to put his newfound appreciation for his grandfather's ways into effect.

Martin and Hazel Quarrier are small-town fundamentalist missionaries sent to the jungles of South America to convert the Indians. Their remote mission was previously run by the Catholics, before the natives murdered them all. They are sent by the pompous Leslie Huben, who runs the missionary effort in the area but who seems more concerned about competing with his Catholic 'rivals' than in the Indians themselves. Hazel is terrified of the Indians while Martin is fascinated. Soon American pilot Lewis Moon joins the Indian tribe but is attracted by Leslie's young wife, Andy. Can the interaction of these characters and cultures, and the advancing bulldozers of civilization, avoid disaster?