Young artist Monte Crandell is being sued for an unauthorized caricature. To escape arrest, he disguises himself as a mystic, only to conjure up a genuine ghost during a seance. Things come to a head during his trial, where the invisible ghost takes the witness stand on Our Hero's behalf.

Two women private detectives arrive at a dude ranch in time to investigate the murder of their client's philandering husband.

Broadway producer Earl Carroll was a Ziegfeld-like entrepreneur who staged lavish revues featuring attractive young ladies. Carroll's annual "Vanities" provided story material for three Hollywood films: Murder at the Vanities (34), A Night at Earl Carroll's (40) and Earl Carroll Vanities (45). This last film was produced by Republic Pictures, a bread-and-butter studio specializing in Westerns and serials; Republic had made musicals before, but few of them were expensive enough to allow for lavish production numbers. Earl Carroll Vanities is likewise rather threadbare, though some of the individual musical highlights aren't bad. The plot, such as it is, concerns financially strapped nightclub owner Eve Arden, who finagles Earl Carroll into staging one of his revues at her club.

Jean Loring has her men illegally killing and selling game. Roy suspects her and gets himself invited to stay at her ranch. Investigating he finds the freezer where the slaughtered game are kept. But he is caught, tied up, and left to freeze.

After one member of their group is murdered, the performers at a burlesque house must work together to find out who the killer is before they strike again.