Isidora, an old woman, discovers that her mind is quickly deteriorating. At an apparently relaxed dinner table, she will desperately try to hide her state from her daughter, a demanding woman who awaits any sign of senility in order to take way everything she has.

Jamie is a boorish, insensitive American twentysomething traveling in Chile, who somehow manages to create chaos at every turn. He and his friends are planning on taking a road trip north to experience a legendary shamanistic hallucinogen called the San Pedro cactus. In a fit of drunkenness at a wild party, Jamie invites an eccentric woman—a radical spirit named Crystal Fairy—to come along.

A gay couple enlists the help of their friend Polly to create a baby. Meanwhile, they must also contend with their homophobic neighbour who becomes a big nuisance.

Tyler joins his friend on a trip to the Catskills for a weekend birthday party with several people he doesn’t know. As soon as they get there, it’s clear that (1) he’s the only black guy, and (2) it’s going to be a weekend of heavy drinking. Although Tyler is welcomed, he can’t help but feel uneasy in “Whitesville.” The combination of all the testosterone and alcohol starts to get out of hand, and Tyler’s precarious situation starts to feel like a nightmare.