A story set in the mid-1800's about a young doctor who has been trained in Western-style medicine and a young samurai who is trying to live up to the old traditions of his class and culture. The story is actually based upon real people - the doctor, Ryo-an, was Tezuka's great grandfather. The manga series was adapted to anime by Madhouse Studios and premiered in Japan on NTV on April 4, 2000.

Two tiny, aquatic humanoids search for their missing father, a boy battles a lethal allergy to eggs, and an invisible salaryman tries to become a hero.