The Prairie is set at the time of the Louisiana Purchase. Hoping to find their destiny in the new territory, the Bush Family heads southward in a covered wagon. Sharing the family's numerous dangers and hardships are Ellen Wade (Lenore Aubert), sole survivor of an Indian attack, and army mapmaker Paul Hover (Alan Baxter). Cousins Abiram (Russ Vincent) and Asa (Jack Mitchum) duke it out over Ellen's affections

Both Indians and cowboys are after a beautiful stallion, the leader of a pack of wild horses.

Tex and sidekick Grass join McGill's traveling show. When Price has McGill's wagons burned, Tex becomes the county tax collector to earn money. This leads to trouble as one of those owing money is Price who says he will not pay. Business doesn´t go as plan.