Margot has always dreamed of becoming a doctor. While struggling to keep up with the grueling pace of the emergency room where she's taking her first steps, the young intern realizes she's seeing more and more young patients suffering from rare diseases. The recurrence of these exceptional cases puzzles her, especially since she's observing some rather mysterious symptoms on her own body. What if all these ailments were actually hiding a completely different truth?

Gab and Driss, childhood friends on bad terms since they left the orphanage, now have opposite lives - one is a cop with the IGPN, the other a fixer for thugs. When their first love dies in a suspicious accident, her 17-year-old daughter, Leïla, takes Gab's gun and sets off on the trail of a powerful organization willing to do anything to cover the case up. Forced to team up, the orphans must stop her before she crosses a line she can't return from...

Following the death of her younger brother during a police intervention, Malika embarks on a legal battle to ensure a trial takes place. However, her quest for truth jeopardizes the stability of her family.