故事围绕着女高中生拯救世界展开，与纪里谷和明以往的男性主人公作品不同，此次的作品有女性担任主角，他也表示这是他最后一部长篇电影，他将使出全力完成这部作品。

Follow the infamous ninja bandit named Ishikawa Goemon (Yosuke Eguchi) in an epic story. One night while looting treasure from Nanban (Southern Barbarians), Goemon finds a mysterious box hidden inside a secret grave. A forgotten relic from the past containing untold powers.

Fifty years of war between the Great Eastern Federation and Europa - now merged as Eurasia - have taken their toll on planet Earth. As a result of the use of biological, chemical and nuclear weapons, much of Earth has become uninhabitable and people have become prey to new diseases. Professor Azuma's "neo-cell" project, which is supposed to be the answer to mankind's hardships, becomes a nightmare come true when mutants spawned from the experiment escape and declare war on the human race. Azuma's son Tetsuya, who was killed during the previous war, is reborn into the cyborg Casshern as mankind's last hope against the new mutant threat. This live-action sci-fi movie based on a 1973 Japanese animé of the same name.