Matt Houston is a millionaire Texan based in Los Angeles. Now among his many businesses is a private investigation agency which for some reason takes up most of his time, which infuriated Murray his business manager, who is left holding the bag. He is assisted by C.J. Parsons, his lawyer and friend. Also seen during the first season was Lt. Vince Novelli, Houston's police contact and friend. Also seen was Vince's mother, who ran a restaurant, which Houston frequented. Also seen were Houston's ranch hands Bo and Lamar. During the second season, Novelli and his mother were gone, and Bo and Lamar were not there that much. Lt. Hoyt was Houston's new contact though they didn't begin amicably. During the third season, Houston's uncle Roy, who was among other things a former CIA agent, joined him and even helped him now and then.

Ian Hart stars in the title role of Dr Hoo as an environmentally conscious, vegetarian Welshman with a multiple personality disorder whose real name is Mr Hugh. Believing the world is coming to an end, he enlists the help of his "sexy bombshell" assistant Zara, played by Elaine Cassidy. She is relying on Dr Hoo to help her "find herself", but she appears to exist only in his head. Stephen Lord the producer and director who also appears in the drama as the mysterious Agent Smart, described the offbeat series as a character-driven show that "allows an audience to think and get what they want from the show – or not, which is liberating".