Luc Deveraux, the heroic former Universal Soldier, is about to be thrown into action once again. When SETH, the supercomputer-controlled ultra-warrior, decides to take revenge and destroy its creators, only Luc can stop it. All hell breaks loose as Luc battles SETH and a deadly team of perfect soldiers in a struggle that pits man against machine and good against evil.

After his wife and daughter are murdered in a home invasion, a widower named John now finds himself up against an army of Universal Soldiers in relentless pursuit, led by a mysterious leader who promises to set UniSols free from their conditioning.

An American soldier who had been killed during the Vietnam War is revived 25 years later by the military as a semi-android, UniSols, a high-tech soldier of the future. After the failure of the initiative to erase all the soldier's memories, he begins to experience flashbacks that are forcing him to recall his past.

20世纪60年代，美国的势力向亚洲渗透，为此政府实行的一项绝密计划——战士再造计划，通过药物注射等手段将士兵大造成冷血无情、实力强悍的超级战士。随着技术不断改进，在罗伯特·柯林博士的主持下又开启了白塔计划，成功打造出更为完美的第二代超级战士。然而一次意外后12名二代战士逃亡，而涉嫌叛国的柯林博士也被驱逐东欧。此后不久，再造战士占领切尔诺贝利，美国军方决定派出4名尚存的一代战士前去击垮那群危险怪物，但是他们全部遭到无情屠戮。
走投无路之际，军方只能派出第五名一代战士卢克·戴沃洛克斯（尚格·云顿 Jean-Claude Van Damme 饰）出马，对抗强大的对手安德鲁·斯科特（杜夫·龙格尔 Dolph Lundgren 饰）……