A car crash victim, humiliated housewife and two repressed teens are connected by their relationships with hard-working therapist Viola, who helps them battle their addictions while two disillusioned detectives struggle with the mounting war against heroin distribution in the Cincinnati area.

Five college friends have a reunion in a castle in Piemonte, Italy. The local legend says the queen of the castle, Johanna of Anjou, was blamed for the local drought and famine. Before she was hung by the villagers, she placed a curse in her journal then killed herself. The group is intrigued by the legend, and one night when drunk, they enter the forbidden room where Joanna died. There, they find her journal. The spirit of Joanna returns, and her thirst for revenge is horrific.

In 1957, insurance investigator George Lazarus is tasked with interviewing twelve employees of the Deadly Sin Cigarette Company when his firm receives a suspicious insurance claim. He learns that all twelve had been let go after contracting mysterious illnesses, but before he can report back, Lazarus goes missing without a trace. After his disappearance, his fiancée Bethany and his friend Chip set out to find him - but what they uncover may actually signal the end of the entire human race.