With the world gripped by a deadly pandemic, science denier Glenn Rollins turns to an experimental vaccine as treatment for a lingering sickness. Much to the surprise of his doctor, wife, and friends, the remedy immediately fixes what ails him. But Glenn will soon discover the only thing more fatal than the virus... is the cure.

Gary is a trailer park romance novelist who can't seem to sleep at night. He also thinks that he saw a monster assaulting his girlfriend while she was sleeping. People is his trailer park begin to die in their sleep. Soon, Gary's friends begin to think that he has gone crazy with all his ranting and raving and that all he needs is a good night's sleep. Gary is afraid to sleep...

While on a stakeout, hardboiled cop Eddie Boone gets injected with a dangerous new designer drug causing nightmarish side effects. As he searches for his missing partner, Eddie discovers the urban streets full of mutants, monsters, and mayhem orchestrated by the mastermind behind the lethal narcotic.