In 1980 Las Vegas, a Native Paiute cleaning lady enters a slots room at the MGM Grand Casino, setting off a chain of strange and unexplained events. Meanwhile, in-house comic Pete plays shrink to a host of colorful misfits while dodging mobsters and collectors. Struggling with a gambling addiction, he faces a life-altering decision that may determine his fate.

After being dumped by her serial killer boyfriend, a beauty-obsessed woman goes on a blood-soaked quest to create the perfect female face, while navigating her new relationship with the cop investigating the murders.