An epic tale of love and sacrifice unfolds in an era of turmoil. The time is 1943. Drawn together by their shared ideals, rebellious girl Chiu Hsueh and gifted student Li Chun-Hsien fall in love and marry, but they are forced apart by the February 28 Incident. Chun-Hsien is exiled to Korea, while Chiu Hsueh and their daughter must live under concealed identities during the White Terror. After several decades, a letter from Korea reveals long-hidden secrets. In this turbulent age of chaos, the untold stories of two generations and three households recount a tale of unfailing love and selfless sacrifice.

Wong Yan Tung, a doctor with a fear of fire and recurring nightmares of being cremated alive, is dedicated to fighting his colleagues' ignorance about the nature of clinical death. Prostitute Kam Kuk, Wong's childhood friend, attempts suicide several times and they inevitably reconnect during her short hospital stays, while Wong's girlfriend suffers from mysterious and sudden bouts of numbness in her arm.

《亂世豪門》自詡以台灣人的觀點，來描寫19世紀末台灣與清廷的關係﹔同時該戲劇也深刻描繪台灣人於日本殖民台灣初期，抗日媚日間的心靈衝突。
可以說是台灣版的《走向共和》。