A year after the death of his friend and partner Sherlock Holmes at the hands of Moriarty, Dr. John Watson resumes his medical career as the head of a clinic dedicated to treating rare disorders. However, he soon finds that his old life is not done with him yet.

Brian Finch's life takes an extraordinary turn when he uses NZT-48, a neuroenhancing drug whose mystery and chaos lead him to working for the FBI and a senator who is not what he seems.