In 1834, Charles Stewart (Alan Ladd), the spoiled, dissolute son of a shipping magnate, is shanghaied aboard the Pilgrim, one of his father's own ships. He embarks upon a long, hellish sea voyage under the tyrannical rule of Captain Francis Thompson (Howard Da Silva), assisted by his first mate, Amazeen (William Bendix). One of his crewmates is Richard Henry Dana Jr. (Brian Donlevy).

"Wicked" Lily Bishop joins a wagon train to California, led by Michael Fabian and Johnnny Trumbo, but news of the Gold Rush scatters the train. When Johnny and Michael finally arrive, Lily is rich from her saloon and storekeeper (former slaver) Pharaoh Coffin is bleeding the miners dry. But worse troubles are ahead: California is inching toward statehood, and certain people want to make it their private empire.

Neale and Pedro fly cargo between Chungking and Calcutta. When their buddy Bill is murdered they investigate. Neale meets Bill's fiancée Virginia and becomes suspicious of a deeper plot while also falling for her charms.