The Mystery Inc. gang investigate more supernatural sightings with the help of the Harlem Globetrotters

A friend of Fred's, Alejo Otero, invites the Scooby gang to Veracruz, Mexico. There they find a monster, El Chupacabra, terrorizing the town.

Aside from doubling the length of each episode, The New Scooby-Doo Movies differed from its predecessor in the addition of a rotating special guest star slot; each episode featured real-life celebrities or well known fictional characters joining the Mystery, Inc. gang in solving the mystery of the week. Some episodes, in particular the episodes guest-starring the characters from The Addams Family, Batman, and Jeannie, deviated from the established Scooby-Doo format of presenting criminals masquerading as supernatural beings by introducing real ghosts, witches, monsters, and other such characters into the plots.

Join the spook-busting, case-cracking, snack-munching fun as Scooby-Doo and the Mystery, Inc. gang gear up for four of their most frightening adventures ever! Traveling the globe on their ongoing quest to trip up crooks (and chow down on munchies), Scooby-Doo, Shaggy, Daphne, Fred and Velma tangle with a supernatural assortment of eerie adversaries. Facing multiple monsters, ghouls galore and gobs of ghosts, our top-dog detective and those "meddling kids" will stop at nothing to get their ghoul as they confront SCOOBY-DOO'S CREEPIEST CAPERS!