In this installment of the Zero Woman series, Rei, the number-one assassin of the Tokyo Police Department's secret Zero Division, has been assigned to take out a notorious gangster responsible for dozens of murders. At the same time, she must protect the gangster's mistress from the hitmen who want to keep her from telling the police what she knows. At first, both women are upset about the arrangement, but they eventually come to appreciate each other.

Two mismatched policewomen are assigned to guard and observe a released prisoner who has connections with a women-only gang who are suspected of counterfeiting.

In Meiji-era Japan, a village of witches and wizards is slaughtered. Years later, an archaeologist discovers a mummy from the village, which reanimates, murders, then possesses his assistant. This evil spirit is now searching for Misa, who is protected by a survivor of the original massacre, known only as Saiga.