After lightning strikes saxophonist Johnny Domino, he finds he is telepathically tuned to the frequency of evil. This gives him an edge for finding the bad guys, and some special classified wearable gear gives him an edge for fighting them.

Night Man is an American action/adventure/sci-fi series that aired in syndication from September 15, 1997 to May 17, 1999. The series is loosely based on a comic book published by Malibu Comics and was created by Steve Englehart and developed for television by Glen A. Larson.

It stars Matt McColm as the title character, a superhero whose real name was Johnny Domino, a saxophonist. Englehart would write three episodes of the series. Night Man is also one of the few series to cross over with characters from Larson's previous series: in the episode "Manimal", Johnny allies with Professor Jonathan Chase, the star of the short-lived 1980s' series Manimal.