描述美国政府的细菌战实验室遭遇意外，一些足以令人致命的病毒从实验室的容器中流失，将实验室中几名科学家杀死。其中最厉害的一种病毒称为“撒旦病菌”，它能够杀死任何人，而这种病菌可能被一名疯子偷去了，于是当局想尽办法追踪捉拿这名疯子。

At the height of the frontier era, a train races through the Rocky Mountains on a classified mission to a remote army post. But one by one the passengers are being murdered, and their only hope is the mysterious John Deakin, who's being transported to face trial for murder.

World War II is raging, and an American general has been captured and is being held hostage in the Schloss Adler, a Bavarian castle that's nearly impossible to breach. It's up to a group of skilled Allied soldiers to liberate the general before it's too late.