The only thing keeping Billy Batson from the girl of his dreams is one little condom—or rather the lack of one. Lucky Billy finds one at an all-night roadhouse—but speeding back to his girl, he is killed in a head-on collision. Now invisible, Billy must find his sweetheart and rekindle her fire.

A genius grad student organizes an all-night treasure hunt in which five rival teams composed of colorful oddballs furiously match wits with one another while trying to locate and decipher various cryptic clues planted ingeniously around Los Angeles.