Pennsylvania, 1993. After getting caught with another girl, teenager Cameron Post is sent to a conversion therapy center run by the strict Dr. Lydia Marsh and her brother, Reverend Rick, whose treatment consists in repenting for feeling “same sex attraction.” Cameron befriends fellow sinners Jane and Adam, thus creating a new family to deal with the surrounding intolerance.

In the summer of 1983, a 17-year-old Elio spends his days in his family's villa in Italy. One day Oliver, a graduate student, arrives to assist Elio's father, a professor of Greco-Roman culture. Soon, Elio and Oliver discover a summer that will alter their lives forever.