A man brutally murders a married couple and leaves the word “ikari” (“rage”) written with their blood. The killer undergoes plastic surgery and flees. At three different locations in Japan, a male stranger appears. People suspect that the stranger might be the murderer.

A teacher lives a lonely life, all the while struggling over his son’s custody. His life slowly gets better as he finds love and receives good news from his son, but his new luck is about to be brutally shattered by an innocent little lie.

Leonard Shelby is tracking down the man who raped and murdered his wife. The difficulty of locating his wife's killer, however, is compounded by the fact that he suffers from a rare, untreatable form of short-term memory loss. Although he can recall details of life before his accident, Leonard cannot remember what happened fifteen minutes ago, where he's going, or why.