Set in a post-apocalyptic world, young Thomas is deposited in a community of boys after his memory is erased, soon learning they're all trapped in a maze that will require him to join forces with fellow “runners” for a shot at escape.

1000年后的世界，日本的孩子们正不断地消失，只存在想象中的恐怖动物与人类展开殊死战斗。反乌托邦式的未来超级社会“新世界”，是口吐真言凭藉“咒力”就能移动物体的人类，与有着等同于普通人智力的生物“化鼠”共存的世界。乍看之下一切和平，但“新世界”的孩子们的行动被彻底地控制和管束着，不合适的记忆被消去，被认为有问题的孩子，如同不良产品般被分开处理。因为一些违反规则的小事而莫名地失去不少朋友的主人公渡边早季，卷进了人类与化鼠之间的战争。

Thomas leads his group of escaped Gladers on their final and most dangerous mission yet. To save their friends, they must break into the legendary Last City, a WCKD-controlled labyrinth that may turn out to be the deadliest maze of all. Anyone who makes it out alive will get answers to the questions the Gladers have been asking since they first arrived in the maze.