After being sworn in by Jack Crawford, the head of the FBI Behavioral Science Unit, to help capture a serial killer who is on the rampage, Will finds himself increasingly struggling to control his thought processes that inform his uncanny ability to empathise with serial killers. When damning evidence shows up at the FBI that implicates Will in a string of grisly murders he is immediately placed under the care of the Baltimore State Hospital for the Criminally Insane. As Will tries to assure Jack of his innocence he also attempts to convince him of the identity of the real killer.

After a particularly grueling case hunting a serial killer known as the Minnesota Shrike, Will Graham threatens to walk away. Jack Crawford, the head of the FBI's Behavioral Science Unit, desperately needs Will on his team to break the tough cases, so he enlists Dr. Hannibal Lecter, to ensure Will's mental well-being. Unbeknownst to Will, Hannibal also has a particular insight into these horrible crimes and the psychopaths who commit them. As Will hunts down brutal killers, he is unknowingly sitting across from the most gifted killer of them all.

After India Stoker's father dies, her Uncle Charlie, who she never knew existed, comes to live with her and her unstable mother. She comes to suspect this mysterious, charming man has ulterior motives and becomes increasingly infatuated with him.

Susan Morrow receives a book manuscript from her ex-husband – a man she left 20 years earlier – asking for her opinion of his writing. As she reads, she is drawn into the fictional life of Tony Hastings, a mathematics professor whose family vacation turns violent.