Famed monster slayer Gabriel Van Helsing is dispatched to Transylvania to assist the last of the Valerious bloodline in defeating Count Dracula. Anna Valerious reveals that Dracula has formed an unholy alliance with Dr. Frankenstein's monster and is hell-bent on exacting a centuries-old curse on her family.

Factory worker Doug Quaid takes a virtual mind-trip vacation with the Rekall company, opting for implanted memories of being a spy. When the procedure goes wrong, Quaid becomes a wanted man by the police and joins forces with a rebel fighter to stop the evil Chancellor Cohaagen.

Having escaped years of imprisonment, vampire warrioress Selene finds herself in a changed world where humans have discovered the existence of both Vampire and Lycan clans and are conducting an all-out war to eradicate both immortal species. Now Selene must battle the humans and a frightening new breed of super Lycans to ensure the death dealers' survival.

The lifelong friendship between Rafe McCawley and Danny Walker is put to the ultimate test when the two ace fighter pilots become entangled in a love triangle with beautiful Naval nurse Evelyn Johnson. But the rivalry between the friends-turned-foes is immediately put on hold when they find themselves at the center of Japan's devastating attack on Pearl Harbor on Dec. 7, 1941.

As the war between the vampires and the Lycans rages on, Selene, a former member of the Death Dealers (an elite vampire special forces unit that hunts werewolves), and Michael, the werewolf hybrid, work together in an effort to unlock the secrets of their respective bloodlines.

Vampires and werewolves have waged a nocturnal war against each other for centuries. But all bets are off when a female vampire warrior named Selene, who's famous for her strength and werewolf-hunting prowess, becomes smitten with a peace-loving male werewolf, Michael, who wants to end the war.

When an uptight young man and his fiancée move into his libertine mother's house, the resulting clash of life attitudes shakes everyone up.