After finding themselves ensnared in a death trap, seven disillusioned castoffs must embark on a dangerous mission that will force them to confront the darkest corners of their pasts.

A listless Wade Wilson toils away in civilian life with his days as the morally flexible mercenary, Deadpool, behind him. But when his homeworld faces an existential threat, Wade must reluctantly suit-up again with an even more reluctant Wolverine.