In the 1820s, a frontiersman, Hugh Glass, sets out on a path of vengeance against those who left him for dead after a bear mauling.

A fatalistic car crash in Mexico city sets off a chain of events in the lives of three people: a supermodel, a young man wanting to run off with his sister-in-law, and a homeless man. Their lives are catapulted into unforeseen situations instigated by the seemingly inconsequential destiny of a dog.