以神奥地区为舞台，加入了许多新登场的神奇宝贝与原有神奇宝贝的新进化型，以此所展开的新冒险。这次同样也可以选择男／女主角进行游戏，没选择的另一位主角会成为支援主角的角色，而不论选择哪一位主角，竞敌都是共通的。此外，这次有敌对组织“银河队”登场。

Set in northern Australia before World War II, an English aristocrat who inherits a sprawling ranch reluctantly pacts with a stock-man in order to protect her new property from a takeover plot. As the pair drive 2,000 head of cattle over unforgiving landscape, they experience the bombing of Darwin by Japanese forces firsthand.

菜月昴（小林裕介 配音）是一位平凡的十七岁高中男生，某日，离开便利店准备回家的他突然被召唤到了异世界。人生地不熟的菜月昂很快就遇到了麻烦，在此危急时刻，名为爱蜜莉雅（高桥李依 配音）的神秘少女带着灵猫帕克（内山夕实 配音）出现在了菜月昂的面前，成为了他的救星，为了报答少 女的恩情，菜月昂和她结伴而行。 让两人没有想到的是，他们竟然遭到了攻击不幸丧命，当菜月昂再度睁开双眼时，却发现自己回到了故事的最初。拥有着“死亡回归”能力的菜月昂决定拯救和少女的命运。菜月昂究竟为何会受到召唤，他又是否能够凭借着自己的特异能力，实现报恩的愿望呢？

A bank teller discovers he is actually a background player in an open-world video game, and decides to become the hero of his own story. Now, in a world where there are no limits, he is determined to be the guy who saves his world his way before it's too late.