The few remaining Salem descendants are under assault by forces of ignorance and hate. The young witches seek refuge at Miss Robichaux's Academy in New Orleans, including new arrival, Zoe, who harbors a terrifying secret of her own. Fiona, a Supreme Witch with unimaginable powers, is determined to protect the Coven, but her obsessive quest for immortality will lead her to cross paths with a voodoo queen and a murderous slave owner cursed with eternal life.

When the Harmon family relocates to a stately mansion in Los Angeles, disturbing secrets start enveloping each of their lives. As they slowly learn about the mysterious and deadly history of their new house, psychiatrist Ben, Vivien and their teenage daughter Violet find themselves surrounded by all manner of menacing spirits, living and dead.

From Nazis and serial killers to mutants and aliens, no one is safe inside the walls of the Briarcliff Mental Institution. In a house of healing that is anything but, troubled nun Sister Jude rules with an iron fist and Dr Arden conducts strange experiments on the facility’s patients.

After a disturbing incident, a young couple move into a seemingly perfect home built in the 18th century. However, the building's proximity to the site of the Lost Colony's disappearance and with horrific events happening at the house the couple start to sense something dark underneath the façade.