During World War II, Steve Rogers is a sickly man from Brooklyn who's transformed into super-soldier Captain America to aid in the war effort. Rogers must stop the Red Skull – Adolf Hitler's ruthless head of weaponry, and the leader of an organization that intends to use a mysterious device of untold powers for world domination.

After the cataclysmic events in New York with The Avengers, Steve Rogers, aka Captain America is living quietly in Washington, D.C. and trying to adjust to the modern world. But when a S.H.I.E.L.D. colleague comes under attack, Steve becomes embroiled in a web of intrigue that threatens to put the world at risk. Joining forces with the Black Widow, Captain America struggles to expose the ever-widening conspiracy while fighting off professional assassins sent to silence him at every turn. When the full scope of the villainous plot is revealed, Captain America and the Black Widow enlist the help of a new ally, the Falcon. However, they soon find themselves up against an unexpected and formidable enemy—the Winter Soldier.