Sam, a neurodivergent man, has a daughter with a homeless woman who abandons them when they leave the hospital, leaving Sam to raise Lucy on his own. But as Lucy grows up, Sam's limitations as a parent start to become a problem and the authorities take her away. Sam convinces high-priced lawyer Rita to take his case pro bono and in turn teaches her the value of love and family.

《小谢尔顿》主创确认第七季为最终季，最终季将于明年2月15日回归，5月16日完结，大结局时长1小时。