As a deadly battle rages over Jigsaw's brutal legacy, a group of Jigsaw survivors gathers to seek the support of self-help guru and fellow survivor Bobby Dagen, a man whose own dark secrets unleash a new wave of terror.

Chev Chelios, a hit man wanting to go straight, lets his latest target slip away. Then he awakes the next morning to a phone call that informs him he has been poisoned and has only an hour to live unless he keeps adrenaline coursing through his body while he searches for an antidote.