Madeleine, rendered mute after being sexually assaulted as a youth, accepts a lift from a wealthy and sadistic pimp who soon enslaves her into his prostitution racket. Despite her limited means, Madeleine embarks on a bloody road to revenge against her captors.

Failed musician Jay abandoned his family and now earns a living as head bartender in a trendy London pub. Every Wednesday afternoon, a woman comes to his house for graphic, almost wordless, sex. One day, Jay follows her and learns about her. This eventually disrupts their relationship.

In post-9/11 New York City, an eclectic group of citizens find their lives entangled, personally, romantically, and sexually, at Shortbus, an underground Brooklyn salon infamous for its blend of art, music, politics, and carnality.

Happily unattached, the sexually voracious Leila satisfies her desires with a host of rapidly changing bed partners, unconcerned about the emotional consequences. But that all changes when she meets an artist looking for a deeper commitment.