The prize: ending the Apocalypse. The price: Sam's life. Season 5's horrific finale left Dean alone, as Sam descended into Hell. Now a different man, Dean vows to stop hunting and devote himself to building a family with Lisa and her son Ben. Then, mysteriously, Sam reappears, drawing Dean back into the old life. But Sam's a different man too. He's returned without his soul. How the Winchesters confront this greatest challenge yet to their powerful bond is the troubled heart - and soul - of the profound and thrilling 22-Episode Season 6. As the brothers struggle to reunite, they must also battle deadly supernatural forces. Demons. Angels. Vampires. Shapeshifters. And a terrifying new foe called the Mother of All.

They're back the ghouls and vampires, the ghosts and spirits and even more terrifying entities. And wherever these evil beings are, you'll find brothers Sam and Dean Winchester, hunters on the trail of the demon who murdered their mother…and of any other unholy agent of the Supernatural. Join the brothers in their mind-bending, bone-chilling Season 2 road trip across America a journey deeper into the mystery of their own destinies.