A man named Seligman finds a fainted wounded woman in an alley and he brings her home. She tells him that her name is Joe and that she is nymphomaniac. Joe tells her life and sexual experiences with hundreds of men since she was a young teenager while Seligman tells about his hobbies, such as fly fishing, reading about Fibonacci numbers or listening to organ music.

A depressed musician reunites with his lover in the desolate streets of Detroit. Though their romance has endured several centuries, it is tested by the arrival of her capricious and unpredictable younger sister.

An awkward office drone becomes increasingly unhinged after a charismatic and confident look-alike takes a job at his workplace and seduces the woman he desires.