In the deep south during the 1930s, three escaped convicts search for hidden treasure while a relentless lawman pursues them. On their journey they come across many comical characters and incredible situations. Based upon Homer's 'Odyssey'.

Llewelyn Moss stumbles upon dead bodies, $2 million and a hoard of heroin in a Texas desert, but methodical killer Anton Chigurh comes looking for it, with local sheriff Ed Tom Bell hot on his trail. The roles of prey and predator blur as the violent pursuit of money and justice collide.