Captain Jack Sparrow crosses paths with a woman from his past, and he's not sure if it's love -- or if she's a ruthless con artist who's using him to find the fabled Fountain of Youth. When she forces him aboard the Queen Anne's Revenge, the ship of the formidable pirate Blackbeard, Jack finds himself on an unexpected adventure in which he doesn't know who to fear more: Blackbeard or the woman from his past.

On his latest expedition, has-been scientist Dr. Rick Marshall is sucked into a space-time vortex alongside his crack-smart research assistant Holly and redneck survivalist Will into a world populated by marauding dinosaurs and painfully slow creatures called Sleestaks. With no weapons, few skills and questionable smarts, the trio must rely on their only ally, a primate named Chaka, to try to survive long enough to figure out a way back home.

Set during the Cold War, the Soviets—led by sword-wielding Irina Spalko—are in search of a crystal skull which has supernatural powers related to a mystical Lost City of Gold. Indy is coerced to head to Peru at the behest of a young man whose friend—and Indy's colleague—Professor Oxley has been captured for his knowledge of the skull's whereabouts.