Living on an estate on the shores of Lake Geneva, Lord Byron is visited by Percy and Mary Shelley. Together with Byron's lover Claire Clairmont, and aided by hallucinogenic substances, they devise an evening of ghoulish tales. However, when confronted by horrors, ostensibly of their own creation, it becomes difficult to tell apparition from reality.

Having grown sick and tired of his centuries as Dracula's lackey, Renfield finds a new lease on life — and maybe even redemption — when he falls for feisty, perennially angry traffic cop Rebecca Quincy.

A publishing executive is visited and bitten by a vampire and starts exhibiting erratic behavior. He pushes his secretary to extremes as he tries to come to terms with his affliction.

The mysterious Count Orlok summons Thomas Hutter to his remote Transylvanian castle in the mountains. The eerie Orlok seeks to buy a house near Hutter and his wife, Ellen. After Orlok reveals his vampire nature, Hutter struggles to escape the castle, knowing that Ellen is in grave danger. Meanwhile Orlok's servant, Knock, prepares for his master to arrive at his new home.

A depressed musician reunites with his lover in the desolate streets of Detroit. Though their romance has endured several centuries, it is tested by the arrival of her capricious and unpredictable younger sister.