The lines between fantasy and reality begin to blur as Kat contemplates ending her relationship and Jules, craving Rue's affection, ponders hers. Rue pursues a new dangerous business venture as she sinks deep into her addiction, largely caused by her guilt-ridden new friend Eliott. Cassie struggles with her celibacy and starts to drift, while Lexi pours herself into mounting a school play. Nate is in full redemption, trying to redeem the mistakes of his father.

Euphoria follows a group of high schoolers as they explore the worlds of drugs, sexuality, and violence.