The spirited Boruto Uzumaki, son of Seventh Hokage Naruto, is a skilled ninja who possesses the same brashness and passion his father once had. However, the constant absence of his father, who is busy with his Hokage duties, puts a damper on Boruto's fire. He ends up meeting his father's friend Sasuke, and requests to become... his apprentice!? The curtain on the story of the new generation rises!

Two years after the events of the Fourth Great Ninja War, the moon that Hagoromo Otsutsuki created long ago to seal away the Gedo Statue begins to descend towards the world, threatening to become a meteor that would destroy everything on impact. Amidst this crisis, a direct descendant of Kaguya Otsutsuki named Toneri Otsutsuki attempts to kidnap Hinata Hyuga but ends up abducting her younger sister Hanabi. Naruto and his allies now mount a rescue mission before finding themselves embroiled in a final battle to decide the fate of everything.

After his capture for attempted assassination of the Raikage, leader of Kumogakure, as well as killing Jōnin from Kirigakure and Iwagakure, Naruto is imprisoned in Hōzukijou: A criminal containment facility known as the Blood Prison. Mui, the castle master, uses the ultimate imprisonment technique to steal power from the prisoners, which is when Naruto notices his life has been targeted. Thus begins the battle to uncover the truth behind the mysterious murders and prove Naruto's innocence.

Demons that once almost destroyed the world, are revived by someone. To prevent the world from being destroyed, the demon has to be sealed and the only one who can do it is the shrine maiden Shion from the country of demons, who has two powers; one is sealing demons and the other is predicting the deaths of humans. This time Naruto's mission is to guard Shion, but she predicts Naruto's death. The only way to escape it, is to get away from Shion, which would leave her unguarded, then the demon, whose only goal is to kill Shion will do so, thus meaning the end of the world. Naruto decides to challenge this "prediction of death."

Sixteen years ago, a mysterious masked ninja unleashes a powerful creature known as the Nine-Tailed Demon Fox on the Hidden Leaf Village Konoha, killing many people. In response, the Fourth Hokage Minato Namikaze and his wife Kushina Uzumaki, the Demon Fox's living prison or Jinchūriki, manage to seal the creature inside their newborn son Naruto Uzumaki. With the Tailed Beast sealed, things continued as normal. However, in the present day, peace ended when a group of ninja called the Akatsuki attack Konoha under the guidance of Tobi, the mysterious masked man behind Fox's rampage years ago who intends on executing his plan to rule the world by shrouding it in illusions.