The second season takes place one-and-a-half years after the first season. Having learned the true nature of the Sibyl System, Akane Tsunemori chose to obey the system, believing in both humanity and the legal order. She's part of a new police section and spends her everyday life facing down criminals. Unbeknownst to Akane, however, a monster who will shake the system to its core is about to appear before her.

The series takes place in the near future, when it is possible to instantaneously measure and quantify a person's state of mind and personality. This information is recorded and processed, and the term "Psycho-Pass" refers to a standard used to measure an individual's being. The story centers around the "enforcement officer" Shinya Kougami, who is tasked with managing crime in such a world.