The prehistoric Croods family live in a particularly dangerous moment in time. Patriarch Grug, his mate Ugga, teenage daughter Eep, son Thunk, and feisty Gran gather food by day and huddle together in a cave at night. When a more evolved caveman named Guy arrives on the scene, Grug is distrustful, but it soon becomes apparent that Guy is correct about the impending destruction of their world.

When Earth is taken over by the overly-confident Boov, an alien race in search of a new place to call home, all humans are promptly relocated, while all Boov get busy reorganizing the planet. But when one resourceful girl, Tip, manages to avoid capture, she finds herself the accidental accomplice of a banished Boov named Oh. The two fugitives realize there’s a lot more at stake than intergalactic relations as they embark on the road trip of a lifetime.